Figure 1.
Effect of DMSO and P2X7 antagonist on monocyte IL‐1β release. LPS priming followed by ATP stimulation resulted in significant IL‐1β release from PBMCs. IL‐1β release was inhibited by the addition of 2% DMSO prior to ATP exposure. Addition of 10 μmol/L P2X7 antagonist had no added effect on the reduction in IL‐1β release. 5 μmol/L BBG had a significant inhibitory effect on monocyte IL‐1β release. Experiments were conducted twice. Data plotted represents mean and standard deviation. (P < 0.05 compared with LPS + ATP).