Table 1.

Physiological and biochemical variables of sham‐operated, untreated septic, and treated septic animals at 6 h and 24 h

	Groups				T‐Test	ANOVA	Post analysis Dunn's T3 test
	Sham‐operated	Untreated Sepsis	DMSO‐ treated	DMSO/A‐438079‐ treated	Sham vs. Untreated	Untreated vs. Treated	Sepsis vs. DMSO	Sepsis vs. DMSO/A‐438079	DMSO vs. DMSO/A438079
6 h
Change in heart rate (%)	−5 (−7−1)	21 (12–26)	15 (7–20)	15 (14–17)	0.0003	0.139	0.284	0.153	0.955
Temperature (°C)	37.4 (37.2–37.6)	38.6 (38.2–39.0)	38.4 (38.3–39.1)	38.7 (38.6–38.8)	0.0009	0.688	0.993	0.649	0.899
Albumin (g/L)	29 (27–30)	26 (24–28)	25 (23–17)	26 (25–29)	0.0242	0.62	0.790	0.961	0.589
Lactate (mmol/L)	1.1 (1.0–1.3)	1.2 (1.0–1.3)	1.0 (0.9–1.0)	1.2 (1.1–1.3)	0.4984	0.051	0.033	0.999	0.084
Creatinine (μmol/L)	25 (23–27)	23 (21–28)	19 (15–25)	25 (24–27)	0.9155	0.547	0.401	0.997	0.034
Renal IL‐1β(pg/mg protein)	86 (50–102)	200 (147–248)	126 (98–220)	70 (55–128)	0.0031	0.077	0.372	0.021	0.372
Serum IL‐1β(pg/mL)	0 (0–10)	1671 (1445–3378)	1924 (1806–2325)	1989 (1214–2362)	<0.0001	0.749	0.807	1.00	0.840
24 h
Change in heart rate (%)	−1 (−4–8)	22 (13–36)	5 (−2–16)	−1 (−6–7)	0.0015	<0.001	0.047	0.019	0.769
Temperature (°C)	37.5 (37.4–37.8)	39.0 (38.6–39.1)	38.3 (37.8–38.5)	38.2 (37.6–38.7)	0.0002	0.011	0.031	0.024	0.996
Albumin (g/L)	30 (29–31)	23 (21–25)	24 (22–25)	27 (25–28)	0.0003	0.002	0.785	0.006	0.016
Lactate (mmol/L)	0.9 (0.2–1.2)	3.2 (2.5–4.3)	2.2 (2.1–2.2)	1.4 (0.9–1.8)	0.0004	<0.001	0.037	0.001	0.001
Creatinine (μmol/L)	23 (22–25)	28 (25–30)	23 (20–26)	22 (17–27)	0.0321	0.005	0.047	0.019	0.769
Renal IL‐1β(pg/mg protein)	168 (154–176)	186 (149–280)	219 (193–260)	224 (147–348)	0.953	0.980	0.999	1.000	0.996
Serum IL‐1β(pg/mL)	0 (0–10)	1463 (927–2541)	1809 (964–2678)	768 (702–1690)	<0.0001	0.141	1.000	0.261	0.207