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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Clin Genet. 2018 Feb 5;93(3):622–631. doi: 10.1111/cge.13142

Figure 2.

Figure 2

Figure 2

Figure 2a. High-resolution chromosome 15 ideogram and SNP microarray results for an individual with Type I (top) and Type II (bottom) PWS deletion genetic subtypes. The genomic copy number is shown on the y-axis. The box indicates the deleted 15q11-q13 region and break points (BP1, BP2 and BP3) and the circle indicates the marker probes differentiating the two deletion subtypes. Figure 2b. High-resolution chromosome microarrays using CNV and SNP probes to identify maternal uniparental disomy 15 subclasses (segmental isodisomy, isodisomy and heterodisomy) in those with an abnormal DNA methylation pattern for PWS. Heterodisomy 15 can resemble normal biparental inheritance.