Table 5.
Comparisons among AFP groups in HCC patients.
| Parameter* | AFP<100 | 100≤AFP≤1000 | AFP>1000 | p-value ψ | Comparisons p-value # | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| (n=1027) | (n=364) | (n=382) | |||||
| (a) | (b) | (c) | (b)vs(a) | (c)vs(a) | (c)vs(b) | ||
| Platelet counts (103/μL) | 148.96±96.31 | 157.14±91.55 | 182.82±106.50 | 0.0001 | 0.06 | <0.0001 | 0.0009 |
| Hemoglobin (g/dL) | 12.36±2.31 | 12.26±2.19 | 12.02±2.33 | 0.04 | 0.70 | 0.02 | 0.06 |
| GGTP (U/L) | 135.73±165.25 | 175.91±162.20 | 203.10±193.38 | 0.0001 | <0.0001 | <0.0001 | 0.17 |
| ALKP (U/L) | 201.94±302.30 | 222.41±213.92 | 240.38±239.29 | 0.0001 | 0.003 | 0.0001 | 0.58 |
| Total Bilirubin (mg/dL) | 2.52±3.76 | 3.68±6.09 | 3.21±4.91 | 0.002 | 0.002 | 0.007 | 0.70 |
| Albumin (g/dL) | 3.17±0.76 | 3.02±0.74 | 2.95±0.71 | 0.0001 | 0.005 | <0.0001 | 0.20 |
| AFP (IU/mL) | 18.10±22.08 | 433.71±296.65 | 25931.36±75120.01 | 0.0001 | <0.0001 | <0.0001 | <0.0001 |
| MTD (cm) | 5.30±3.71 | 6.29±4.09 | 7.54±4.35 | 0.0001 | <0.0001 | <0.0001 | 0.0001 |
| Nodules number (%) | 0.04 ^ | ||||||
| 1 | 633 (70.65) | 212 (66.04) | 202 (61.77) | 0.13 § | 0.004 § | 0.26 § | |
| 2–3 | 262 (29.24) | 109 (33.96) | 124 (37.92) | 0.12 § | 0.005 § | 0.29 § | |
| >3 | 1 (0.11) | 0 (0.00) | 1 (0.31) | 0.32 § | 0.55 § | 0.32 § | |
| PV Thrombosis (%) | 184 (21.03) | 105 (34.09) | 145 (44.48) | <0.001 ^ | <0.0001 § | <0.0001 § | 0.007 § |
| Cirrhosis (%) | 803 (79.11) | 304 (83.98) | 325 (85.08) | 0.01 ^ | 0.04 § | 0.007 § | 0.68 § |
*
All values: Means±Standard Deviation as continuous; Frequences and percentage (%) as categorical.
ψ
Kruskal-Wallis rank test;
#
Wilcoxon rank-sum (Mann-Whitney) test;
^
Chi-square test;
§
Test z for proportions.
Abbreviations: GGTP, gamma glutamyl transpeptidae; ALKP, Alkaline phosphatase; AFP, Alpha-fetoprotein; MTD, Maximum Tumor Diameter; PVT, Portal Vein Thrombosis.