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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Clin Exp Allergy. 2018 Jan 22;48(3):288–296. doi: 10.1111/cea.13075

Figure 5.

Figure 5

Induction of ILC2-derived IL-13 and its impact on anaphylaxis. A) IL-13 secretion by ILC2 stimulated by IgE+Ag-activated BMMC. Role of IL-4 in MC-stimulated ILC2 IL-13 secretion. Statistical analysis by one-way ANOVA with Bonferroni post-tests. B) Anaphylaxis in mice passively sensitized with IgE anti-TNP (2μg) at −16h and challenged with TNP-OVA (20μg) by i.p. injection (n=3–4). Activated, flow-sorted ILC2 (2×105) were transferred via i.v. injection at −16h. C) Core body temperature loss after administration of 1mg histamine (n=4–5). D) Core body temperature loss after administration of 1mg serotonin (n=4–5). Statistical analysis by repeated measures 2-way ANOVA with Bonferroni post-tests at individual time points. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Data are representative of two independent experiments each.