Table 2.

Sex differences in aSyn and 13a2-aSyn mice.

Test	Age (m)	Females				Males
		WT	13a2	aSyn	13a2-aSyn	WT	13a2	aSyn	13a2-aSyn
Beam: Errors per Step	2	0.16 ± 0.01	0.16 ± 0.01	0.23 ± 0.02	0.29 ± 0.03	0.17 ± 0.01	0.15 ± 0.02	0.76 ± 0.05***	0.83 ± 0.05***
	4	0.13 ± 0.02	0.16 ± 0.02	0.26 ± 0.02	0.35 ± 0.03	0.17 ± 0.02	0.16 ± 0.02	0.93 ± 0.05***	0.93 ± 0.08***
	6	0.16 ± 0.02	0.14 ± 0.02	0.27 ± 0.03	0.38 ± 0.03	0.14 ± 0.01	0.13 ± 0.01	1.01 ± 0.08***	1.08 ± 0.04***
Cylinder: Hindlimb Steps	2	33.67 ± 5.65	33.77 ± 4.74	17.69 ± 1.93	26.07 ± 6.66	27.08 ± 4.31	30.29 ± 3.38	9.31 ± 2.79*	7.85 ± 1.63*
	4	28.80 ± 5.70	25.31 ± 4.22	15.08 ± 2.25	17.79 ± 1.97	22.54 ± 4.82	17.00 ± 3.86	7.69 ± 1.51*	6.85 ± 2.46***
	6	25.33 ± 4.04	28.15 ± 5.47	25.31 ± 5.96	22.00 ± 4.39	19.08 ± 3.52	19.71 ± 2.82	4.77 ± 1.80**	1.58 ± 0.65***
Adhesive Removal	2	3.13 ± 0.66	2.36 ± 0.42	2.46 ± 0.41	2.57 ± 0.71	2.26 ± 0.27	2.24 ± 0.43	4.64 ± 0.98	6.56 ± 1.36*
	4	2.51 ± 0.60	2.20 ± 0.33	4.80 ± 1.15	4.40 ± 0.69	5.10 ± 1.60	2.29 ± 0.41	14.4 ± 1.74***	20.85 ± 3.27***
	6	1.93 ± 0.20	2.20 ± 0.30	11.80 ± 3.63	11.88 ± 3.29	3.36 ± 0.53	3.12 ± 0.60	24.23 ± 5.10	31.59 ± 5.21**

Mean ± SEM shown. WT= wildtype, 13a2= ATP13A2 knockout mice, aSyn= alpha-synuclein overexpressing, and 13a2-aSyn= double mutant ATP13A2 knockout with overexpression of alpha-synuclein.

^{*, **, ***} represents p<0.05, 0.01, 0.001 respectively compared to Females of the same genotype and age. 2X3 Mixed Design ANOVA, Tukey’s HSD post hoc.