Table 3.
Summary of sensorimotor alterations in female 13a2, aSyn, ad 13a2-aSyn mice.
| Sensorimotor Test | 2m | 4m | 6m | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| 13a2 | aSyn | 13a2 aSyn | 13a2 | aSyn | 13a2 aSyn | 13a2 | aSyn | 13a2 aSyn | |
| Adhesive Removal | |||||||||
| Removal latency | = | = | = | = | = | = | = | ↑ | ↑ |
| ⇑ | ⇑ | ||||||||
| Challenging Beam | |||||||||
| Errors per | = | ↑ | ↑↑ | = | ↑↑ | ↑↑ | = | ↑ | ↑↑ |
| Step | ⇑ | ||||||||
| Time | = | = | = | = | = | = | = | = | = |
| Steps | = | = | = | = | = | = | = | = | = |
| Spontaneous Activity (Cylinder) | |||||||||
| Rears | = | = | = | = | = | = | = | = | = |
| FLSteps | = | = | = | = | = | = | = | = | = |
| HLSteps | = | = | = | = | = | = | = | = | = |
| Grooming | = | = | = | = | = | = | = | = | = |
| Gait | |||||||||
| Stride Length | = | = | = | = | = | = | = | = | = |
| Maximum difference | = | = | = | = | = | = | ⇑ | = | = |
| Locomotor Activity (Open Field) | |||||||||
| Line Crosses | = | = | ↑ | = | ↑↑ | ↑↑ | = | ↑↑ | ↑↑ |
| ⇑⇑ | ⇑⇑ | ⇑ | |||||||
| Rears | = | = | = | = | = | ↑ | = | ↑ | |
| ⇑⇑ | ⇑⇑ | ⇑⇑ | ⇑ | ||||||
| Nestbuilding | |||||||||
| % Cotton Used | = | ↓↓ | ↓ | = | ↓↓ | ↓↓ | = | ↓↓↓ | ↓↓↓ |
| ⇓ | |||||||||
↑, ↑↑, ↑↑↑ represents significant increase at p<0.05, 0.01, 0.001, respectively, compared to WT at the same age. ↓, ↓↓, ↓↓↓ represents significant decrease at p<0.05, 0.01, 0.001, respectively, compared to WT at the same age. ⇑, ⇑⇑ represents significant increase at p<0.05, 0.01, respectively, compared to same genotype at 2m. ⇓, ⇓⇓ represents significant decrease at p<0.05, 0.01, respectively, compared to same genotype at 2m.