Table 4.
Summary of sensorimotor alterations in male 13a2, aSyn, ad 13a2-aSyn mice.
| Sensorimotor Test | 2m | 4m | 6m | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| 13a2 | aSyn | 13a2 aSyn | 13a2 | aSyn | 13a2 aSyn | 13a2 | aSyn | 13a2 aSyn | |
| Adhesive Removal | |||||||||
| Removal latency | = | = | ↑ | = | ↑↑ | ↑↑↑ | = | ↑↑↑ | ↑↑↑ |
| ⇑⇑ | ⇑⇑ | ⇑⇑ | ⇑⇑ | ||||||
| Challenging Beam | |||||||||
| Errors per Step | = | ↑↑↑ | ↑↑↑ | = | ↑↑↑ | ↑↑↑ | = | ↑↑↑ | ↑↑↑ |
| ⇑⇑ | ⇑⇑ | ⇑⇑ | |||||||
| Time | = | = | = | = | = | = | = | ⇑⇑ | = |
| Steps | = | ↓ | = | = | ↓ | = | = | ↓↓ | ↓↓↓ |
| Spontaneous Activity (Cylinder) | |||||||||
| Rears | = | = | = | = | = | = | = | = | ↓ |
| ⇓ | |||||||||
| FLSteps | = | = | = | = | = | = | ⇓ | ⇓⇓ | ↓ |
| HLSteps | = | ↓↓ | ↓↓ | = | ↓↓ | ↓↓ | = | ↓↓ | ↓↓ |
| ⇓ | |||||||||
| Grooming | = | ↓↓ | ↓ | = | = | = | ↓ | ↓↓ | = |
| Gait | |||||||||
| Stride Length | = | = | = | = | = | = | = | = | = |
| Maximum difference | = | = | = | = | = | = | = | = | = |
| Locomotor Activity (Open Field) | |||||||||
| Line Crosses | = | ↑ | = | = | ↑↑↑ | ↑↑ | = | = | = |
| ⇑ | ⇑ | ||||||||
| Rears | = | = | = | = | ↑↑↑ | ↑ | = | = | = |
| ⇑ | ⇑ | ||||||||
| Nestbuilding | |||||||||
| % Cotton Used | = | ↓↓↓ | ↓↓ | = | ↓↓↓ | ↓↓ | = | ↓↓↓ | ↓↓ |
↑, ↑↑, ↑↑↑ represents significant increase at p<0.05, 0.01, 0.001, respectively, compared to WT at the same age. ↓, ↓↓, ↓↓↓ represents significant decrease at p<0.05, 0.01, 0.001, respectively, compared to WT at the same age. ⇑, ⇑⇑ represents significant increase at p<0.05, 0.01, respectively, compared to same genotype at 2m. ⇓, ⇓⇓ represents significant decrease at p<0.05, 0.01, respectively, compared to same genotype at 2m.