Table 1.
Patient and hospital level characteristics of mild ischemic stroke patients (NIHSS≤5) in the FL-PR Stroke Registry stratified by thrombolysis treatment
| Clinical Characteristics | All (n=6,826) |
Thrombolysis (n=1,281) |
No Thrombolysis (n=5,545) |
p value |
|---|---|---|---|---|
|
| ||||
| Age (yrs), median (IQR) | 72 (21) | 68 (20) | 72 (21) | <.0001 |
|
| ||||
| Sex (male), % | 3,598 (52.7) | 718 (56.1) | 2880 (51.9) | <.0001 |
|
| ||||
| Vascular Risk Factor, % | ||||
|
| ||||
| Current smoker | 1,048 (15.4) | 248 (19.4) | 800 (14.4) | <.0001 |
|
| ||||
| Hypertension | 4,713 (69.0) | 745 (58.2) | 3,968 (71.6) | <.0001 |
|
| ||||
| Diabetes mellitus | 1,839 (26.9) | 304 (23.7) | 1,535 (27.7) | 0.004 |
|
| ||||
| Dyslipidemia | 2,990 (43.8) | 428 (33.4) | 2,562 (46.2) | < .0001 |
|
| ||||
| Medical History, % | ||||
|
| ||||
| AF | 1,067 (15.6) | 187 (14.6) | 880 (15.9) | 0.26 |
|
| ||||
| CAD/prior MI | 1,733 (25.4) | 260 (20.3) | 1,473 (26.6) | <.0001 |
|
| ||||
| Previous stroke/TIA | 1,911 (28.0) | 233 (18.2) | 1,678 (30.3) | <.0001 |
|
| ||||
| Ethnicity, % | ||||
| NH- white | 4,798(70.3) | 855 (66.7) | 3,943 (71.1) | <.0001 |
| NH- black | 881 (12.9) | 174 (13.6) | 707 (12.8) | |
| FL-Hispanic | 889 (13.0) | 173 (13.5) | 716 (12.9) | |
| PR-Hispanic | 258 (3.8) | 79 (6.2) | 179 (3.2) | |
|
| ||||
| Medical Insurance, % | ||||
| Private* | 2,777 (40.7) | 498 (38.9) | 2,279 (41.1) | <.0001 |
| Medicare | 2,112 (30.9) | 311 (24.3) | 1,801 (32.5) | |
| Medicaid/No Insurance** | 645 (9.5) | 147 (11.5) | 498 (9.0) | |
| Unknown | 1,292 (18.9) | 325 (25.4) | 967 (17.4) | |
|
| ||||
| Arrival Time (%) | ||||
| On –hours | 3,241 (47.5) | 629 (49.1) | 2,612 (47.1) | 0.20 |
| Off- hours | 3,585 (52.5) | 652 (50.9) | 2,933 (52.9) | |
|
| ||||
| Arrival Time from Onset Minutes (median, IQR) | 76 (85) | 63 (64) | 81 (92) | 0.001 |
|
| ||||
| Arrival Time from Onset Minutes | ||||
| 0 to 2 hour | 4861 (71.2) | 1061 (82.8) | 3800 (68.5) | <.0001 |
| 2 to 3.5 hour | 1600 (23.4) | 206 (16.1) | 1394 (25.1) | |
| 3.5 hour and above | 365 (5.4) | 14 (1.1) | 351 (6.3) | |
|
| ||||
| Final Diagnosis TIA | 1,735 (25.4) | 32 (2.5) | 1,703 (30.7) | <.0001 |
|
| ||||
| NIHSS (median), IQR | 2 (3) | 4 (2) | 2 (2) | <.0001 |
|
| ||||
| Clinical Signs/symptoms, % | ||||
|
| ||||
| Weakness | 3,420 (50.1) | 738 (57.6) | 2,682 (48.4) | <.0001 |
|
| ||||
| Aphasia | 2,253 (33.0) | 533 (41.6) | 1,720 (31.0) | <.0001 |
|
| ||||
| Altered level of Consciousness | 494 (7.2) | 67 (5.2) | 427 (7.7) | 0.002 |
|
| ||||
| Other Neurological Signs/symptoms | 1,120 (16.4) | 188 (14.7) | 932 (16.8) | 0.06 |
|
| ||||
| No Neurological Signs/symptoms | 57 (0.8) | 2 (0.2) | 55 (1.0) | 0.003 |
|
| ||||
| Mode of Arrival EMS | ||||
| Yes | 3,748 (54.9) | 821 (64.1) | 2,927 (52.8) | <.0001 |
| No | 2585 (37.9) | 346 (27.0) | 2239 (40.4) | |
| Missing | 493 (7.2) | 114 (8.9) | 379 (6.8) | |
|
| ||||
| Door to CT time minutes (median, IQR) | 27(35) | 20 (20) | 30(40) | <.0001 |
|
| ||||
| Door to CT time (% <25 min) | 3,029 (46.7) | 792 (65.0) | 2,237 (42.5) | <.0001 |
|
| ||||
| Hospital Characteristics | ||||
|
| ||||
| Hospital Size | ||||
| Median bed (IQR) | 468 (387) | 466 (462) | 468 (396) | <.0001 |
| Small (<250beds) | 1355(19.8) | 201 (15.7) | 1154 (20.8) | |
| Mid (250–450 beds) | 1658 (24.3) | 367 (28.7) | 1291 (23.3) | |
| Large (>450) | 3813 (55.9) | 713 (55.7) | 3100 (55.9) | |
|
| ||||
| Academic hospital, % | ||||
| Yes | 1207 (17.7) | 398 (31.1) | 809 (14.6) | <.0001 |
| No | 5619 (82.3) | 883 (68.9) | 4736 (85.4) | |
|
| ||||
| Years in GWTG, median (IQR) | 8 (2) | 7 (3) | 8 (2) | <.0001 |
|
| ||||
| Number of tPA treated patients peryear | <.0001 | |||
| Low volume (<100) | 3291 (48.2) | 503 (39.3) | 2788 (50.3) | |
| High volume (≥100) | 3535 (51.8 | 778 (60.7) | 2757 (49.7) | |
|
| ||||
| State | ||||
| Florida | 6568 (96.2) | 1202 (93.8) | 5366 (96.8) | <.0001 |
| Puerto Rico | 258 (3.8) | 79 (6.2) | 179 (3.2) | |
|
| ||||
| Stroke Center Type | <.0001 | |||
| Primary Stroke Center | 3054 (44.7) | 477 (37.2) | 2577 (46.5) | |
| Comprehensive Stroke Center | 3611 (52.9) | 749 (58.5) | 2862 (51.6) | |
| Not Primary/Comprehensive | 161 (2.4) | 55 (4.3) | 106 (1.9) | |
|
| ||||
| Region in Florida | ||||
| South | 2402 (36.6) | 517 (43.0) | 1885 (35.1) | <.0001 |
| East Central | 918 (14.0) | 205 (17.1) | 713 (13.3) | |
| West Central | 2286 (34.8) | 232 (19.3) | 2054 (38.3) | |
| North and Panhandle | 962 (14.7) | 248 (20.6) | 714 (13.3) | |
AF=atrial fibrillation, CAD= Coronary Artery Disease, MI=Myocardial Infarction. NH-White= Non-Hispanic White, NH-black= Non-Hispanic black. EMS= Emergency Medical Services.
*
Includes Private insurance, VA and other.
**
Includes Medicaid, self-pay and No insurance.