Table 1.

The list of laforin sequences used in the present study.^a

No.	Taxonomy	Organism	GenBank	UniProt	Source	Length	Copy 1	Copy 2	Copy 3	DSP
1	Vertebrata	Homo sapiens	AAG18377.1	O95278	CAZy database	331	1–124			138–322
2	Vertebrata	Gallus gallus	AAR21595.1	Q5ZL46	BLAST-O95278	319	1–111			125–309
3	Vertebrata	Tetraodon nigroviridis	CAG03589.1	Q4S6Z3	BLAST-O95278	312	1–106			120–305
4	Vertebrata	Alligator mississippiensis	KYO37738.1	A0A151NLS3	BLAST-O95278	305	1–99			113–297
5	Vertebrata	Xenopus laevis	AAH73202.1	Q6GPD8	BLAST-O95278	313	1–106			120–304
6	Cephalochordata	Branchiostoma floridae	EEN49019.1	C3ZE63	BLAST-O95278	316	1–117			131–316
7	Cnidaria	Exaiptasia pallida	KXJ09946.1	---	BLAST-O95278	324	1–118			132–313
8	Cnidaria	Nematostella vectensis	EDO32135.1	A7SVW9	BLAST-O95278	324	1–118			132–313
9	Chromerida	Vitrella brassicaformis	CEL97703.1	A0A0G4ELK3	BLAST-O95278	358	1–139			152–337
10	Nematoda	Trichinella britovi	KRY46872.1	A0A0V1CCK1	BLAST-O95278	361	1–104			118–299
11	Nematoda	Trichinella murrelli	KRX36920.1	A0A0V0TD31	BLAST-O95278	360	1–104			118–299
12	Nematoda	Trichinella papuae	KRZ74431.1	A0A0V1MS55	BLAST-O95278	312	1–104			118299
13	Nematoda	Trichinella pseudospiralis	KRY67691.1	A0A0V1E1K1	BLAST-O95278	314	1–104			118–301
14	Nematoda	Trichinella sp. T8	KRZ83465.1	A0A0V1NHG2	BLAST-O95278	361	1–104			118–299
15	Nematoda	Trichinella spiralis	EFV53640.1	E5SNJ4	BLAST-O95278	347	1–104			118–288
16	Rhodophyta	Cyanidioschyzon merolae	BAM83396.1	M1UXX5	Ref [47]	532	165–265	270–370		380–525
17	Rhodophyta	Chondrus crispus	CDF36183.1	R7QEI4	BLAST-M1UXX5	549	1–100	176–278	285–387	401–545
18	Cryptophyta	Guillardia theta	EKX31889.1	L1I7M6	BLAST-M1UXX5	611	97–182	209–294	317–421	455–607
19	Ciliophora	Paramecium tetraurelia	CAK57701.1	A0BGN4	Ref [47]	726	257–356	365–460		538–685
20	Ciliophora	Tetrahymena thermophila	EAR89845.2	Q22X01	Ref [47]	480	58–162	163–267		270–420
21	Ciliophora	Oxytricha trifallax	EJY86497.1	J9IW88	BLAST-M1UXX5	474	49–177	182–283		320–470
22	Ciliophora	Stylonychia lemnae	CDW83192.1	A0A078APE9	BLAST-M1UXX5	545	200–250	255–357		399–545
23	Apicomplexa	Eimeria tenella	CDJ40554.1	U6KW34	Ref. [47]	459	1–254			269–450
24	Apicomplexa	Toxoplasma gondii	EPT29986.1	S8F2K7	Ref. [47]	523	1–312			327–508
25	Apicomplexa	Eimeria acervulina	CDI81398.1	U6GQ52	BLAST-U6KW34	1435	856–1108			1115–1233
26	Apicomplexa	Eimeria brunetti	CDJ47235.1	U6LHG3	BLAST-S8F2K7	1418	965–1218			1233–1414
27	Apicomplexa	Eimeria maxima	CDJ57191.1	U6LZL6	BLAST-S8F2K7	1392	924–1177			1206–1387
28	Apicomplexa	Eimeria mitis	CDJ36110.1	U6KDK1	BLAST-S8F2K7	740	288–541			556–737
29	Apicomplexa	Eimeria necatrix	CDJ62429.1	U6MIY3	BLAST-S8F2K7	459	1–254			269–450
30	Apicomplexa	Eimeria praecox	CDI86477.1	U6H3K9	BLAST-S8F2K7	1365	913–1165			1180–1361
31	Apicomplexa	Hammondia hammondi	KEP61982.1	A0A074TJ74	BLAST-S8F2K7	523	1–312			327–508
32	Apicomplexa	Neospora caninum	CBZ52253.1	F0VEV9	BLAST-S8F2K7	524	1–312			327–508

^aTable contains sequences of both experimentally characterized and putative laforin orthologues from several groups: (i) representatives of vertebrates (mammals, birds, fishes, reptiles and amphibians; all in green); (ii) non-vertebrates represented by phyla Cephalochordata (walnut), Cnidaria (cyan), Chromerida (orange) and Nematoda (magenta); (iii) red and cryptomonad algae (blue); and (iv) protozoans represented by phyla Ciliophora (gold) and Apicomplexa (red). GenBank [51] and UniProt [52] are the accession numbers of sequences from the two databases (if available). Source indicates the way how the sequence was found; BLAST followed by a UniProt accession number means that a sequence was found in the BLAST search using the UniProt’s sequence as a query. Length is the number of amino acid residues in the protein. The three columns with “copies” show the boundaries of CBM20 that may be present in more copies within a single laforin’s sequence. The last column “DSP” indicates the boundaries of the catalytic DSP domain.