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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cell Signal. 2018 Jan 10;44:92–102. doi: 10.1016/j.cellsig.2018.01.009

Figure 1. The process of protein modification by neddylation.

Figure 1

Neddylation is a process that conjugates NEDD8, an ubiquitin-like molecule, to targeted protein substrates via enzymatic cascades involving NEDD8-activating enzyme E1, NEDD8-conjuagating enzyme E2 and substrate-specific NEDD8-E3 ligases. Shown are reported neddylation E3s and substrates. The substrates were divided into cullins and non-cullins. N8: NEDD8.