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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cell Signal. 2018 Jan 10;44:92–102. doi: 10.1016/j.cellsig.2018.01.009

Figure 2. Neddylation activates CRLs to regulate tumorigenesis.

Figure 2

In normal cells, neddylation and deneddylation are kept in a balanced status to ensure hemostasis. During tumorigenesis, CRLs are activated to selectively promote ubiquitylation and degradation of tumor suppressors, thus accelerating tumor growth. Blockage of neddylation by MLN4924 or other E2s/E3s inhibitors would inactivate CRLs to cause the accumulation of tumor suppressor substrates to inhibit tumor growth.