Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cell Signal. 2018 Jan 10;44:92–102. doi: 10.1016/j.cellsig.2018.01.009

Figure 4. Rational drug combinational design.

Figure 4

Neddylation inactivation by MLN4924 triggers protective autophagy in cancer cells through the blockage of mTOR signals via the accumulation of DEPTOR and the activation of the HIF1α-DDIT4/REDD1-TSC1/2 axis. Thus, combination of MLN4924 with small molecule inhibitors of autophagy (e.g. chloroquine) leads to an increased suppression of tumor growth by enhancing NOXA-dependent apoptosis via triggering DNA damage and ROS generation.