Table 1.
Clinicaltrial. gov identifier | Phase | Tumor type | Time initiated | With conbination | Antitumor activity | Ref |
---|---|---|---|---|---|---|
NCT00677170 | I | Solid tumor | May 2008 | Alone | 9 SDs | [61] |
NCT00722488 | I | HL, HM, MM, lymphoma | July 2008 | Alone | 1 PR | [62] |
NCT00911066 | I | AML, ALL, MS | May 2009 | Alone With azacitidine |
4 CRs | [63] |
NCT01011530 | I | Metastatic melanoma | November 2009 | Alone | 9 SDs 1 PR |
[64] |
NCT01862328 | Ib | Solid tumor | May 2013 | With docetaxel With gemcitabine With carboplatin +paclitaxel |
NR | |
NCT01814826 | Ib | AML | March 2013 | With azacitidine | 6 CRs 4 PRs |
[65] |
NCT02610777 | II | AML | November 2015 | with azacitidine versus single-agent azacitidine | NR |
AML: Acute myeloid leukemia; ALL: acute lymphoblastic leukemia; CR: Complete response; HL: Hodgkin lymphoma; HM: hematologic malignancies; MM: multiple myeloma; MS: myelodysplastic syndrome; NR: not reported; PR: partial response; SD: stable disease.