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. 2018 Feb 23;9:132. doi: 10.3389/fphys.2018.00132

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Copyright © 2018 Morrison, Kleemann, van Koppen, Hanemaaijer and Verschuren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of human inflammation-related upstream regulators in HFD-fed Ldlr^−/−.Leiden mice. (A) Venn diagram to visualize the overlap in upstream regulators between human NASH biopsies (red circle) and Ldlr^−/−.Leiden mice (blue circle). (B) Heatmap visualization of direction of regulation (Z-score). Red color indicates activated upstream regulator and green color indicates inhibited upstream regulator.