Table 1.
Significantly modulated inflammation-related upstream regulators in human NASH vs. control.
| NASH vs. CTRL | ||
|---|---|---|
| Upstream regulator | Activation z-score | p-value |
| TNF | 2.426 | 0.00000011 |
| CEBPA | 2.149 | 0.0000251 |
| CSF2 | 3.144 | 0.0000448 |
| IGF1 | 3.918 | 0.000118 |
| SP1 | 3.14 | 0.000154 |
| IL5 | 1.86 | 0.000213 |
| DSP | −2.219 | 0.000327 |
| TGM2 | 2.18 | 0.000372 |
| ERG | 3.035 | 0.000386 |
| TGFB1 | 2.64 | 0.00051 |
| ERBB2 | 3.393 | 0.00064 |
| SREBF2 | 3.115 | 0.000703 |
| PARP2 | 1.987 | 0.000706 |
| ATP7B | 2.646 | 0.000872 |
| MLXIPL | 2.198 | 0.00113 |
| RUNX3 | −1.982 | 0.00125 |
| SNAI1 | 2.219 | 0.00183 |
| ESR2 | 2.316 | 0.00254 |
| EGR1 | 2.381 | 0.00264 |
| CREBBP | 2.266 | 0.00265 |
| PLG | 2.121 | 0.00298 |
| FGF2 | 2.203 | 0.00317 |
| ETS2 | 2.158 | 0.0051 |
| AHR | −3.035 | 0.00528 |
| RHOA | 2.63 | 0.00694 |
| TET2 | 2.111 | 0.00708 |
| GLI1 | 2.072 | 0.00841 |
The z-score indicates the predicted activation state of a transcription factor or key regulator: z ≤ −2 indicates relevant inhibition (shown in green), z ≥ 2 indicates relevant activation (shown in red). The p-value indicates significant enrichment of the genes downstream of a regulator (p < 0.01 was considered statistically significant).