Table 2.
Significantly modulated inflammation-related upstream regulators in HFD-fed Ldlr−/−.Leiden mice vs. chow.
| HFD vs. Chow | ||
|---|---|---|
| Upstream regulator | Activation z-score | p-value |
| TGFB1 | 7.849 | 1.96E-57 |
| TNF | 9.244 | 6.44E-52 |
| IFNG | 8.757 | 3.3E-47 |
| TP53 | 2.363 | 9.73E-42 |
| IL1B | 7.97 | 4.03E-34 |
| ERBB2 | 2.374 | 1.38E-32 |
| IL6 | 4.47 | 1.68E-32 |
| IL13 | 3.514 | 3.49E-30 |
| IL10RA | −3.494 | 2.83E-26 |
| IL4 | 3.087 | 3.12E-26 |
| AHR | −3.408 | 1.99E-25 |
| NFKBIA | 3.976 | 3.41E-22 |
| SP1 | 3.337 | 3.99E-22 |
| STAT3 | 2.572 | 5.1E-22 |
| CSF2 | 6.882 | 3.02E-21 |
| IL2 | 5.83 | 1.65E-18 |
| JUN | 3.138 | 3.34E-18 |
| SREBF2 | −4.082 | 5.14E-18 |
| IKBKB | 4.584 | 4.38E-17 |
| STAT1 | 6.505 | 5.96E-17 |
| IFNB1 | 3.99 | 6.31E-17 |
| CSF1 | 4.48 | 1.59E-16 |
| CSF3 | 2.881 | 9.27E-16 |
| CD44 | 5.442 | 9.32E-16 |
| CEBPB | 2.814 | 5.24E-15 |
| TGM2 | 5.805 | 1.16E-14 |
| IL1 | 5.181 | 1.66E-14 |
| EGF | 4.346 | 4.27E-14 |
| IL5 | 4.57 | 4.3E-14 |
| MYD88 | 6.236 | 4.42E-14 |
| TLR4 | 6.077 | 9.01E-14 |
| IL17A | 4.377 | 3.69E-13 |
| IKBKG | 4.505 | 5.84E-13 |
| IL3 | 3.661 | 1.73E-12 |
| IGF1 | 3.725 | 7.38E-12 |
| IL1A | 5.712 | 1.55E-11 |
| CREBBP | 2.868 | 3.2E-11 |
| STAT4 | 4.14 | 3.74E-11 |
| TLR3 | 5.923 | 4.1E-11 |
| FOXO1 | 3.171 | 4.13E-11 |
| TLR9 | 5.532 | 4.79E-11 |
| FGF2 | 3.295 | 8.43E-11 |
| HGF | 3.624 | 1.64E-10 |
| EGR1 | 3.58 | 2.35E-10 |
| CCL5 | 2.583 | 4.74E-10 |
| NFKB1 | 4.307 | 6.73E-10 |
| SMAD3 | 4.858 | 2.92E-09 |
| RELA | 4.325 | 4.43E-09 |
| ATP7B | −3.771 | 4.66E-09 |
| CXCL12 | 4.638 | 1.09E-08 |
| IL15 | 3.372 | 1.72E-08 |
| JUNB | 2.91 | 5.15E-08 |
| SPDEF | −3.725 | 5.64E-08 |
| TNFSF12 | 4.161 | 7.22E-08 |
| FGFR2 | 2.368 | 1.05E-07 |
| TGFA | 2.134 | 2.15E-07 |
| LIF | 2.452 | 4.86E-07 |
| IL1RN | −4.697 | 7.80E-07 |
| IL18 | 5.15 | 8.27E-07 |
| IL21 | 3.514 | 1.84E-06 |
| CCL2 | 2.23 | 2.04E-06 |
| ERG | 5.112 | 2.09E-06 |
| CXCL3 | 3.109 | 3.39E-06 |
| CXCL2 | 3.057 | 3.39E-06 |
| Ccl2 | 2.497 | 4.70E-06 |
| WNT3A | 2.287 | 4.90E-06 |
| PLG | 4.065 | 5.59E-06 |
| TET2 | 2.828 | 6.97E-06 |
| KLF4 | 3.272 | 9.16E-06 |
| IL27 | 4.527 | 1.10E-05 |
| CEBPD | 2.434 | 1.21E-05 |
| MIF | 4.191 | 1.32E-05 |
| TLR7 | 5.145 | 1.35E-05 |
| SMAD1 | 2.3 | 4.74E-05 |
| GLI1 | 2.211 | 1.02E-04 |
| FOXA3 | −2.093 | 1.06E-04 |
The z-score indicates the predicted activation state of a transcription factor or key regulator: z ≤ −2 indicates relevant inhibition (shown in green), z ≥ 2 indicates relevant activation (shown in red). The p-value indicates significant enrichment of the genes downstream of a regulator (p < 0.001 was considered statistically significant).