Table 3.

Overlap analysis of significantly regulated pathways in human and murine NASH.

		Human NASH vs. CTRL	Ldlr−/−.Leiden mouse HFD vs. chow
No.	Canonical Pathway	−log(p-value)	−log(p-value)
PATHWAYS REGULATED BOTH IN HUMAN NASH AND MURINE NASH
1	Fcγ Receptor-mediated phagocytosis in macrophages and monocytes	5.44	12.5
2	PI3K signaling in B lymphocytes	3.77	7.2
3	Leukocyte extravasation signaling	3.56	6.29
4	IL-8 signaling	3.05	9.48
5	Natural killer cell signaling	2.95	5.82
6	Macropinocytosis signaling	2.87	4.78
7	B Cell receptor signaling	2.54	4.89
8	Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis	2.53	5.74
9	Production of nitric oxide and reactive oxygen species in macrophages	2.36	7.98
10	Dendritic cell maturation	2.05	6.5
11	iCOS-iCOSL signaling in T helper cells	2.04	5.35
PATHWAYS REGULATED ONLY IN MURINE NASH
1	CD28 signaling in T helper cells	1.82	5.51
2	Crosstalk between dendritic cells and natural killer cells	1.61	4.05
3	T cell receptor signaling	1.53	3.02
4	Acute phase response signaling	1.43	6.84
5	PKCθ signaling in T lymphocytes	1.43	4.58
6	IL-10 signaling	1.28	4.56
7	IL-12 signaling and production in macrophages	1.18	4.02
8	LPS/IL-1 mediated inhibition of RXR function	0.981	7.85
9	Altered T cell and B cell signaling in rheumatoid arthritis	0.833	5.41
10	Th1 and Th2 activation pathway	0.505	4.19
11	NF-κB signaling	0.375	5.21
12	Th2 pathway	0.26	3.11
13	T helper cell differentiation	0.254	3.57
14	Toll-like receptor signaling	0.247	6.11
15	Inflammasome pathway	0.242	3.42
16	Th1 Pathway	N/A	3.98
PATHWAYS REGULATED ONLY IN HUMAN NASH
1	Chemokine signaling	2.16	2.44
2	LPS-stimulated MAPK signaling	2.16	2.99

Significance of enrichment for canonical pathways is indicated by –log(p-value).