Figure 1.

Therapeutic targeting cell metabolism in the tumor microenvironment (TME). (A) Tumor cells create a hostile TME that affects metabolic fitness of T cells through multiple ways. T cells are challenged by different immunologic and metabolic checkpoints: Glucose and amino acid depletion, high acidity and lactate, and upregulation of immune checkpoints influence T cell metabolism to suppress glycolysis thereby reducing their activation and proliferation. (B) Currently, several novel promising approaches are proposed to rewire metabolic fitness of T cells in the TME and to boost existing immunotherapies.