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. 2018 Feb 27;8:3689. doi: 10.1038/s41598-018-21853-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of autophagy preserves mitochondrial contents and ameliorates cell death in compressed skeletal muscle. (a) to (d) show the comparison of animals (n = 4 mice/group; WT, Bak^−/−, and Bax^−/−Bak^−/− mice in this order) injected with the autophagy inhibitor colchicine for (a) amounts of p62 and L3C-I/II proteins by Western blots, and (b) mitochondrial complexes, including complexes I-V, by Western blots, (c) DNA fragmentation, and (d) rotarod performance in control (“−” or clear bars) and compressed (“+” or shaded black bars) muscle tissues. All values are expressed as means ± standard error of mean. Pairwise comparison was performed with Student’s t-test, *P < 0.05, **P < 0.01. One-way analysis of variance (ANOVA) and Tukey’s post hoc test were used to compare multiple groups, ^#P < 0.05.