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. 2018 Feb 27;8:3692. doi: 10.1038/s41598-018-22049-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Destructive changes in actin microfilaments in the near-membrane layer of the olfactory knob in an OSN; this layer is partially preserved in the axial cylinder of the dendrite. The bulk of the nuclear material is inside the dendrite. Staining for F-actin (FITC phalloidin, green) and for nuclei (DAPI, blue); laser confocal microscopy (2D section). (a) A view of the surface of the olfactory epithelium; a mesh network of actin microfilaments associated with tight junctions is clear; (а1 and а2) orthogonal projections of OSNs. The large meshes formed by actin microfilaments are attributed to the apexes of supporting cells. Notation: 1 – Dendrite of OSN that contact the surface of the olfactory epithelium; 2 – Profile of the apical section of a mature OSN; 3 – Profile of the apical section of the SC. The blue arrows show the direction to the surface of the olfactory epithelium.