Table 3.
Clinical and demographic characteristics of patients who developed post-polypectomy colorectal cancer at site distinct from index AA/TSA/ASSA polypectomy n (%)
| Characteristics | Patients with post-polypectomy CRC (n = 54) | Patients who did not develop CRC (n = 162) | P value1 |
| Demographics | |||
| Male sex | 27 (50.0) | 88 (54.3) | 0.58 |
| Age ≥ 70 | 26 (48.2) | 52 (32.1) | 0.04 |
| Time interval from first treatment for advanced adenoma till cancer or last surveillance colonoscopy in years (median, IQR) | 5.11 (2.67-10.37) | 6.8 (4.0-10.26) | 0.08 |
| Number of colonoscopies between first polypectomy and cancer (mean ± SD) | 1.24 ± 1.58 | 1.65±1.68 | 0.03 |
| Adenoma size (10-20 mm) | 25 (48.1) | 106 (65.8) | 0.03 |
| Adenoma size (≥ 20 mm) | 9 (17.3) | 20 (12.4) | 0.51 |
| Flat/sessile | 47 (92.2) | 91 (58.71) | < 0.01 |
| Degree of dysplasia | |||
| High grade | 17 (31.5) | 51(31.5) | - |
| Low grade/no dysplasia | 37 (68.5) | 111 (68.5) | - |
| Number of attempts to remove the polyp (mean ± SD) | 1.35 ± 0.68 | 1.33 ± 0.68 | < 0.01 |
| Number of polyps resected at polypectomy (> 3 polyps) | 11 (20.4) | 15 (9.5%) | 0.04 |
| Polypectomy Device used | |||
| Hot snare | 12 (22.2) | 26(16.05) | 0.63 |
| Cold snare | 4 (7.4) | 12(7.0) | 0.63 |
| Snare NOS | 38 (70.5) | 127 (76.5) | 0.63 |
| Additional treatments | |||
| Piecemeal removal | 9 (16.7) | 21(13.0) | 0.5 |
| Injection-assisted EMR | 3 (5.6) | 16 (10.0) | 0.33 |
| Polyp location | |||
| Right colon | 31 (57.4) | 40 (24.7) | < 0.01 |
| Left colon | 13 (24.1) | 89 (54.9) | < 0.01 |
| Rectum | 10 (18.5) | 33 (20.4) | < 0.01 |
1
P-values for continuous variables were obtained using the Kruskal-Wallis Test; Pearson’s chi-square test was used for discrete variables. CRC: Colorectal cancer.