Table 3.
Hazard ratios for end-stage renal disease in the untreated hepatitis B virus-infected and hepatitis B virus-uninfected chronic kidney disease patients, with adjustment for competing mortality
| Variable | Overall CKD patients (n = 103002) |
Propensity score-matched CKD patients (n = 14580) |
||||||
| Crude |
Adjusted1 |
Crude |
Adjusted1 |
|||||
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| CKD patients | ||||||||
| Uninfected | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||
| Untreated | 1.39 (1.20-1.60) | < 0.0001 | 1.69 (1.47-1.96) | < 0.0001 | 1.64 (1.38-1.94) | < 0.0001 | 1.67 (1.40-1.98) | < 0.0001 |
| Sex (Men/Women) | 0.94 (0.88-0.99) | 0.028 | 1.38 (1.25-1.51) | < 0.0001 | 1.24 (1.05-1.46) | 0.011 | 1.65 (1.26-2.16) | 0.0003 |
| Age (per year) | 1.01 (1.01-1.01) | < 0.0001 | 0.96 (0.96-0.97) | < 0.0001 | 1.03 (1.02-1.03) | < 0.0001 | 0.98 (0.96-0.98) | 0.012 |
| Comorbidity (Yes/No) | ||||||||
| Diabetes | 2.49 (2.35-2.65) | < 0.0001 | 1.96 (1.83-2.10) | < 0.0001 | 2.55 (2.18-2.99) | < 0.0001 | 1.96 (1.63-2.35) | < 0.0001 |
| Hypertension | 2.85 (2.67-3.03) | < 0.0001 | 2.08 (1.88-2.29) | < 0.0001 | 3.59 (3.06-4.20) | < 0.0001 | 2.51 (1.95-3.22) | < 0.0001 |
| Coronary heart disease | 1.26 (1.17-1.35) | < 0.0001 | 0.86 (0.80-1.05) | 0.37 | 1.25 (0.98-1.60) | 0.08 | 0.93 (0.74-1.15) | 0.49 |
| Hyperlipidemia | 1.16 (1.08-1.24) | < 0.0001 | 1.01 (0.93-1.08) | 0.90 | 1.07 (0.89-1.30) | 0.48 | 0.84 (0.68-1.03) | 0.09 |
| Cirrhosis | 0.81 (0.62-1.05) | 0.11 | 8.34 (5.72-12.17) | < 0.0001 | 0.73 (0.46-1.15) | 0.17 | 4.36 (1.56-12.17) | 0.005 |
| Urbanization level | ||||||||
| Urban | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||
| Suburban | 1.01 (0.95-1.08) | 0.69 | 0.93 (0.87-1.00) | 0.06 | 1.10 (0.94-1.28) | 0.26 | 0.99 (0.81-1.19) | 0.87 |
| Rural | 1.03 (0.97-1.11) | 0.35 | 0.84 (0.77-1.03) | 0.07 | 0.99 (0.82-1.20) | 0.94 | 0.80 (0.63-1.01) | 0.06 |
| Enrolee category | ||||||||
| 1 + 2 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||
| 3 | 1.28 (1.21-1.36) | < 0.0001 | 1.34 (1.23-1.47) | < 0.0001 | 1.36 (1.16-1.60) | 0.0001 | 1.44 (1.15-1.79) | 0.001 |
| 4 | 1.26 (1.18-1.35) | < 0.0001 | 1.34 (1.21-1.49) | < 0.0001 | 1.52 (1.27-1.82) | < 0.0001 | 1.55 (1.21-1.98) | 0.0006 |
1
Adjusted for all covariates (age per year, sex, comorbidities, urbanization level, enrolee category, number of medical visits, Charlson comorbidity index score, and propensity score) and competing mortality. CKD: Chronic kidney disease.