Figure 5.

Proposed model of how deglycosylation of DMP1 affects astrocyte maturation and BBB integrity. Under physiological conditions, showed in WT, astrocytes could accurately target to brain blood vessels, wrap around vessels, and seal the cell gaps between endothelial cells through cell-cell interaction. When the GAG chain of DMP1 is lost during pathological state, astrocytes shrink, and signified by the reduction of AQP4 and laminin. As a result, astrocytes have attenuated their propensity of targeting to vessels, and fail to accomplish the sealing function, leading to BBB leakage