Figure 6.

Cardiac Tissue-like Constructs Improved the Function of the Infarcted Heart

(A and B) Capillary formation at the peri-ischemic zone in MI heart 4 weeks after transplantation of CTLCs (A) or acellular control (B). The sections are immunostained with CD31. Scale bars, 100 μm.

(C) Quantification of the density of CD31-positive capillaries. Data are represented as means ± SD. CTLC, n = 7 rats; control, n = 6 rats. ^∗p < 0.05 by Student's t test.

(D–G) Change of ejection fraction (D), fractional shortening (E), left ventricular end-systolic diameter (LVESD; F), and left ventricular end-diastolic diameter (LVEDD; G) of infarct rat heart following CTLC transplantation versus the control group at 0 weeks and 4 weeks after transplantation. Data are represented as means ± SD. CTLC, n = 12 rats; control, n = 17 rats. ^∗p < 0.05 and ^∗∗∗p < 0.001 by one-way ANOVA followed by Tukey's post hoc test.

See also Figure S7.