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. 2018 Jan 10;7(1):bio025734. doi: 10.1242/bio.025734

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Zebrafish lacking prion protein (prp2^−/−) displayed an age-dependent decline in memory as revealed by the D2 discrimination index. (A) 1-year-old prp2^−/− zebrafish displayed familiar object preference following a 1-min retention interval, while the 1-year-old prp2^+/+ fish did not, as revealed by the D2 index of object preference (# indicates significant difference from 0 at P<0.05 using the one sample t-test; n=13 prp2^+/+ fish, n=28 prp2^−/− fish). (B) 3-year-old fish of both genotypes (prp2^+/+ and prp2^−/−) failed to show object preference following a 1-min retention interval using the D2 discrimination index (n=16 fish/genotype). (C) Zebrafish lacking prion protein (prp2^−/−) displayed a small, though not statistically significant, reduction in familiar object preference with age as measured by D2 (values replotted from Fig. 3A,B).