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. 2018 Jan 15;7(1):bio031435. doi: 10.1242/bio.031435

Fig. 1.

Fig. 1.

The ICD of Crb restores epithelial integrity of crb mutant embryos. (A) Schematic representation of the fosmids. Depicted proteins are based on the Crb-PA isoform (2.146 amino acids). Adopted from Klose et al. (2013). (B) Analysis of embryonic lethality. The graph represents the percent of embryos that hatch. N>1000 embryos. The experiment was repeated 5 times. Error bars show standard error of the mean. (C-I) Classification of cuticle phenotypes of unhatched embryos. White arrowhead (D,E,F,G), intact head structure; yellow arrow (D,F), intact denticle belts; magenta arrowheads (D), fused or lost denticle belts; cyan arrowhead (E,F), dorsal/ventral hole, respectively; cyan arrowheads (G), ventral and dorsal hole. Scale bar: 50 μm. (J) Quantification of cuticle phenotypes. N>300 embryos. The experiment was repeated 3 times.