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. 2018 Jan 15;7(1):bio031435. doi: 10.1242/bio.031435

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — The Crb ICD is sufficient for tissue integrity of most embryonic epithelia. (A-F) Stage 12-13 embryos, stained for SAS. Dotted lines in E and F mark the disintegrated ventral epidermis. Dorsal is up, anterior left. Scale bar: 50 μm. The experiment was repeated 3 times. (G-N) Stage 12-13 foscrb; crb^GX24 control (G-J) and foscrb_ICD crb^11A22 (K-N) embryos, stained with anti-SAS. Polarity of epithelial tubes is restored in the hindgut (G,K), the Malpighian tubules (H,L), the salivary gland (I,M) and the trachea (J,N). Scale bar: 10 μm. (O-R″) Stills of time lapse movies of endogenously tagged DE-Cadherin-GFP lines. Dorsal (O-P″) and lateral (Q-R″) views of foscrb; crb^GX24 control and foscrb_ICD crb^11A22 embryos. Red dotted lines in P,P′ mark the disintegrated ventral epidermis. Yellow arrow in P, disintegrated head epidermis; cyan arrowhead in P″, recovered head epidermis; red arrowheads in R′,R″, ‘wounds’ in ventral epidermis. Anterior is to the left. Scale bar: 50 μm. The experiment was repeated 3 times.