Fig. 6.

The effects of doxorubicin (20 μM, 24 hours) on adult cardiomyocyte viability with reduced CYP2J2 expression due to 72 hours of silencing with siRNA. Shown are the effects of cotreatment with EETs (50 nM total) on cell viability, using either combination or individual EETs. The data presented are the mean and S.D. of a single experiment in triplicate. Data were normalized to cells treated with scrambled siRNA for 72 hours, followed by vehicle treatment of 24 hours. The P values were determined using unpaired t test. ***P < 0.001.