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. 2018 Feb 20;12:89. doi: 10.3389/fnins.2018.00089

Figure 4.

Figure 4

Reduced IL-1β, IL-6, MMP-9, and MMP-3 expression with L-902,688 treatment. (A) IL-1β is decreased in the ipsilateral cortex (**P = 0.0082) in rats given L-902,688. (B) There was a non-significant (P = 0.0888), but substantial decrease in IL-1β in the ipsilateral subcortex. (C) IL-6 is significantly downregulated in the ipsilateral cortex (**P = 0.0089) and slightly reduced in the subcortex (D) (P = 0.1186). (E) L-902,688 decreased MMP-9 in the ipsilateral cortex (***P < 0.001) (F) There was a trend toward MMP-9 downregulation with treatment in the ipsilateral subcortex, but it did not reach significance (P = 0.2335). (G) EP4 receptor activation with L-902,688 potently reduces MMP-3 mRNA expression in the ischemic cerebral cortex (**P = 0.0083). (H) No significant reduction in MMP-3 expression was found in the ischemic subcortical region between treatment groups (P = 0.5104). Student's t-test comparing vehicle and L-902,688 ipsilateral groups. CXI, ipsilateral cortex; CXC, contralateral cortex; STI, ipsilateral subcortex; STC, contralateral subcortex. Vehicle (n = 10) and 1.0 mg/kg L-902,688 (n = 8).