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Strategies to design rWC parallel si-duplexes targeting Bcl-2 incorporating iG and iC, with guide strand antiparallel (A and C) and parallel (B) to the mRNA. In all cases the si-duplex, itself, is parallel stranded. Codes: DNA residues shown in black (d-iC underlined), RNA residues shown in blue (r-iC underlined).
