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. 2017 Dec 12;46(4):1756–1776. doi: 10.1093/nar/gkx1225

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Largazole spares most super-enhancers in RPE cells. (A) Delineation of super-enhancers in RPE cells based on RNAPII occupancy in untreated and largazole exposed HCT116 cells using the ROSE algorithm. Screenshot of Genome Browser (UCSC) encompassing three super-enhancers near the locus of the (a) NEAT1, (b) MALAT1 lncRNAs, and the (c) FOSL1 gene in (B) RPE and (C) HCT116 cells. (D) Real time quantitative PCR analysis of mRNA levels in HCT116 and RPE cells exposed for 16 h to 75 nM largazole. Data are represented as mean ± S.E.M. (n = 2).