Table 1. EC50 and TC50 summary for analogs.
| Compound | EC50 (μM) | TC50 (μM) | TC50/EC50 ratio |
|---|---|---|---|
| UNC7938 | 3.6 | 28.0 | 7.7 |
| UNC4954 | 14.0 | 55.0 | 3.9 |
| UNC5059 | 4.3 | 33.0 | 7.6 |
| UNC5103 | 4.0 | 23.0 | 5.8 |
| UNC5127 | 21.0 | 47.5 | 2.3 |
| UNC5163 | 3.8 | 21.5 | 5.7 |
| UNC4093 | >30 | ND | - |
| UNC4102 | >30 | ND | - |
| B-36 | >30 | ND | - |
| B-48 | 8.0 | 80.0 | 10.0 |
| B-65 | 14.0 | 80.0 | 5.7 |
| B-78 | >30 | ND | - |
| B-116 | 4.5 | 41.0 | 9.1 |
| B-128 | 8.5 | 41.0 | 4.8 |
| B-136 | 4.0 | 20.0 | 5.0 |
| B-141 | 1.8 | 13.0 | 7.2 |
| B-152 | 3.1 | 18 | 5.8 |
| B1–225 | >30 | ND | - |
| B1–250 | >30 | ND | - |
| B1–257-2 | >30 | ND | - |
| B1–252-P | 20 | 54.0 | 2.7 |
ND = not determined.
EC50 and TC50 values are averages from two to three experiments where each experiment used the same batch of cells and stock of compound for the functional assay and the cytotoxicity assay.