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. 2018 Jan 18;46(4):1601–1613. doi: 10.1093/nar/gkx1320

Table 1. EC50 and TC50 summary for analogs.

Compound EC50 (μM) TC50 (μM) TC50/EC50 ratio
UNC7938 3.6 28.0 7.7
UNC4954 14.0 55.0 3.9
UNC5059 4.3 33.0 7.6
UNC5103 4.0 23.0 5.8
UNC5127 21.0 47.5 2.3
UNC5163 3.8 21.5 5.7
UNC4093 >30 ND -
UNC4102 >30 ND -
B-36 >30 ND -
B-48 8.0 80.0 10.0
B-65 14.0 80.0 5.7
B-78 >30 ND -
B-116 4.5 41.0 9.1
B-128 8.5 41.0 4.8
B-136 4.0 20.0 5.0
B-141 1.8 13.0 7.2
B-152 3.1 18 5.8
B1–225 >30 ND -
B1–250 >30 ND -
B1–257-2 >30 ND -
B1–252-P 20 54.0 2.7

ND = not determined.

EC50 and TC50 values are averages from two to three experiments where each experiment used the same batch of cells and stock of compound for the functional assay and the cytotoxicity assay.