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. 2018 Jan 30;46(4):1565–1583. doi: 10.1093/nar/gky068

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Hypomodification of the taurine modification in a patient with pathogenic mutations in GTPBP3. XICs of anticodon-containing RNase T₁-digested fragments with different modifications of mt-tRNAs for Leu(UUR) (A), Trp (B), Gln (C), Glu (D) and Lys (E), isolated from neonatal human dermal fibroblast (NHDF) (left panels) and patient fibroblasts (right panels). Sequence of the detected fragment, with its m/z value and charge state, is indicated on the right. Relative frequencies of τm⁵(s²)U in the patient sample are indicated in the bottom chromatograms. n.d., not detected. ms²i⁶A, 2-methylthio-N⁶-isopentenyladenosine; i⁶A, N⁶-isopentenyladenosine.