. 2018 Feb 6;8(2):e020991. doi: 10.1136/bmjopen-2017-020991

Table 7.

Summary of GRADE evidence profile of clindamycin vs early cephalosporins

Outcome/timeframe	Study results and measurements	Absolute effect estimates		Certainty in effect estimates (quality of evidence)	Plain text summary
Outcome/timeframe	Study results and measurements	Cephalosporins	Clindamycin	Certainty in effect estimates (quality of evidence)	Plain text summary
Treatment failure/1 month	OR 0.39 (95% CI 0.11 to 1.02) Based on data from 1572 patients in five studies Follow-up 7–21 days	280 per 1000	109 per 1000	Moderate Due to serious imprecision*	Clindamycin probably reduces the risk of treatment failure.
Treatment failure/1 month		Difference: 171 fewer per 1000 (95% CI 401 fewer to 2 more)		Moderate Due to serious imprecision*	Clindamycin probably reduces the risk of treatment failure.

*Imprecision: serious. CI includes no difference.

GRADE, Grading of Recommendations Assessment, Development and Evaluation.