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. 2018 Feb 28;4(2):eaao0665. doi: 10.1126/sciadv.aao0665

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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) Intraindividual AF of 28S rRNA sequence variant A2538G, by population (max V_st = 0.56). X axis has log₂ scaling. (B to D) Tertiary structures of the ribosome showing strongly population-stratified variants (V_st > 0.5) with high intraindividual AF (>20%) in any individual analyzed that are located (B) in expansion segments (ES6^S and ES3) in the surface near ribosomal protein eS6, (C) proximal to the binding site for ribosomal protein eS19, and (D) proximal to the binding site for ribosomal protein eL38. Ribosome tertiary structures [Protein Data Bank (PDB) ID 4V6X (67)] show rRNA (tan), ribosomal proteins (green), and key structural landmarks.