(a) Biomarker coexpression in blood from healthy women and patients in phases I (before treatment) and II (after treatment)

Biomarker coexpression	Healthy women		Patients				P value
			Phase I		Phase II
	(N = 30)		(N = 30)		(N = 30)
	Positive		Positive		Positive		P1	P2	P3
CK19, Ki-67, Myc, CEA	2	6%	13	43%	0	0%	0.00	NS	0.00
CK19, Ki-67, Myc	2	6%	13	43%	0	0%	0.00	NS	0.00
CK19, Ki-67	19	63%	22	73%	10	33%	NS	0.02	0.00

P value ≤ 0.05 was considered statistically significant;P1 was considered between phase I and healthy women; P2 was considered between phase II and healthy women; P3 was considered between phases I and II.