(a).

Study 6 mo treatment period	Relative risk of experiencing ≥1 confirmed (blood glucose ≤ 70 mg/dL) or severe episode of hypoglycemia (95% CI)						Relative risk (95% CI) of documented symptomatic hypoglycemia (<54 mg/dL)
	Nocturnal (00:00–05:59 h)			At any time (24 h)			At any time	Nocturnal
	BL to W8	W9 to month 6	BL to month 6	BL to W8	W9 to month 6	BL to month 6	BL to month 6	BL to month 6
EDITION 1	0.79 (0.64 to 0.98)	0.79 (0.67 to 0.93)	0.78 (0.68 to 0.89)	0.86 (0.78 to 0.94)	0.96 (0.89 to 1.04)	0.93 (0.88 to 0.99)	0.90 (0.76 to 1.07)	0.72 (0.51 to 1.01)
EDITION 2	0.53 (0.39 to 0.72)	0.77 (0.60 to 0.97)	0.71 (0.58 to 0.86)	0.78 (0.69 to 0.89)	0.91 (0.82 to 1.02)	0.90 (0.83 to 0.98)	0.77 (0.60 to 0.98)	0.71 (0.46 to 1.08)
EDITION 3	0.74 (0.48 to 1.13)	0.90 (0.67 to 1.22)	0.76 (0.59 to 0.99)	0.83 (0.67 to 1.03)	0.86 (0.74 to 1.00)	0.88 (0.77 to 1.01)	0.55 (0.37 to 0.82)	0.51 (0.27 to 0.94)
EDITION 4	0.82 (0.70 to 0.96)	1.06 (0.92 to 1.23)	0.98 (0.88 to 1.09)	0.98 (0.92 to 1.04)	0.98 (0.91 to 1.06)	1.00 (0.95 to 1.04)	0.99 (0.88 to 1.11)	1.05 (0.86 to 1.29)
EDITION JP1	0.71 (0.56 to 0.91)	0.84 (0.70 to 1.00)	0.85 (0.73 to 0.99)	0.91 (0.84 to 0.99)	1.01 (0.95 to 1.08)	0.99 (0.95 to 1.04)	0.87 (0.75 to 1.00)	0.64 (0.47 to 0.88)
EDITION JP2	0.83 (0.45 to 1.52)	0.58 (0.40 to 0.85)	0.62 (0.44 to 0.88)	0.69 (0.52 to 0.91)	0.84 (0.70 to 1.01)	0.86 (0.73 to 1.01)	1.44 (0.67 to 3.10)	1.17 (0.48 to 2.84)