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. 2017 Oct 12;9(5):1573–1587. doi: 10.1016/j.stemcr.2017.09.009

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Gene Activation upon Treatment with a Combination of HDAC and EZH2 Inhibitors Is Reversible

(A) Transcript levels of indicated genes were measured by qRT-PCR at the indicated times after removal of the GSK-343/panobinostat drug combination. qRT-PCR values are expressed as mean percentages of vehicle-treated cells ±SEM with B2M serving as internal control. (n = 3).

(B and C) Enrichment of H3K27me3 (B) and H3 acetyl (C) histone marks is measured by ChIP-qPCR at the indicated times after removal of the GSK-343/panobinostat drug combination. qPCR values are expressed as mean fractions of input ±SD.

^∗∗∗p < 0.001; ^∗∗p < 0.01; ^∗p < 0.05; ns, non-significant.