Table 2.

Evidence Opposing Cognitive Impairment

Study	Study Design	Statin	Participants	Findings/Relevance
Ott BR, et al., 2015, [5]	Systematic review and meta-analysis	All	56,655	Statin therapy was not associated with cognitive impairment in RCTs.
Richardson K, et al., 2013, [21]	Systematic review	All	56,043	Larger and better-designed studies are needed to draw unequivocal conclusions about the effect of statins on cognition. Published data do not suggest an adverse effect of statins on cognition; however, the strength of available evidence is limited, particularly with regard to high-dose statins.
Benito-León J, et al., 2010, [22]	Population based study	Ator, flu, lova, prav, sim,	548	Statin users and controls performed similarly on neuropsychological tests.
Lilly SM, et al., 2014, [23]	Retrospective database investigational study	Ator, flu, lova, prava, rosu, sim	13,626	Non-persistent statin users had a greater risk of being diagnosed with schizophrenia/psychosis and cognitive disorders compared with persistent users.
Swiger KJ, et al., 2013, [24]	Systematic review and meta-analysis	All	23,541	In patients without baseline cognitive dysfunction, the results of the available studies are most compatible with no significant short-term cognitive detriments related to statin therapy, whereas long-term data suggest a beneficial role in the prevention of dementia.
McGuiness B, et al., 2016, [11]	Systematic review	Prava, Sim	26,340	There were no differences between statin and placebo groups on five different cognitive tests.

ator atorvastatin, flu fluvastatin, lova lovastatin, prav pravastatin, rosu rosuvastatin, sim simvastatin