Table 3.
Full Cohort
|
Propensity Matched Cohort
|
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---|---|---|---|---|---|---|
Univariate
|
Multivariate*
|
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HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
Stroke | 0.86 (0.82–0.91) | <0.0001 | 0.91 (0.86–0.96) | 0.001 | 0.88 (0.83–0.94) | 0.0003 |
Overall Mortality | 0.82 (0.81–0.84) | <0.0001 | 0.89 (0.88–0.91) | <0.0001 | 0.90 (0.88–0.92) | <0.0001 |
Cardiovascular mortality† | 0.82 (0.79–0.85) | <0.0001 | 0.88 (0.84–0.91) | <0.0001 | 0.90 (0.86–0.94) | <0.0001 |
TIA | 0.99 (0.87–0.93) | 0.87 | 0.95 (0.87–1.04) | 0.27 | 0.99 (0.89–1.10) | 0.88 |
Heart Failure | 1.18 (1.16–1.21) | <0.0001 | 1.02 (1.00–1.05) | 0.088 | 1.07 (1.04–1.10) | <0.0001 |
AF/SVT | 1.71 (1.67–1.74) | <0.0001 | 1.38 (1.35–1.42) | <0.0001 | 1.44 (1.41–1.48) | <0.0001 |
Myocardial Infarction | 1.23 (1.20–1.26) | <0.0001 | 1.03 (1.00–1.05) | 0.04 | 1.08 (1.05–1.11) | <0.0001 |
AF: atrial fibrillation, HR: hazard ratio, SVT: supraventricular tachycardia), TIA: transient ischemic attack
Multivariate model includes: demographics (age, patient distance to clinic/medical center, race, sex, and VA priority status), comorbidities (Charlson comorbidity index, diabetes, heart failure, hypertension, Selim comorbidity index, stroke/transient ischemic attack, and glomerular filtration rate), non AF medications (antiplatelet, ACE inhibitor/angiotensin receptor blocker, diuretics, niacin/fibrates, and statins), and AF medications (amiodarone, anticoagulation [warfarin/novel oral anticoagulant], beta blockers, calcium channel blockers, class I agents, class III agents, digoxin),
Death preceded by cardiovascular hospitalization within 30 days