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. Author manuscript; available in PMC: 2018 Aug 14.
Published in final edited form as: Integr Biol (Camb). 2017 Aug 14;9(8):695–708. doi: 10.1039/c7ib00070g

Figure 1.

Figure 1

HS1 stabilizes branched actin filaments at the leading edge of DCs. (a) Structure of HS1. The NTA domain, shown in red, binds to the Arp 2/3 complex. The helix-turn-helix domain and coiled-coil domains, shown in blue, bind to F-actin. A proline rich domain, SH3 domain and important tyrosine residues are located at the C-terminus. (b) Cartoon representation of branched actin structure in lamellipodia. Red represents the Arp 2/3 Complex and blue represents actin. HS1 (chain of colored circles) is thought to stabilize actin branch points by simultaneously binding the Arp 2/3 Complex and neighboring F-actin.