Table 1.
Participant characteristics by genotype.
| COMT | BDNF | APOE | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| A/A | A/G | G/G | p-value | G/G | A/G | A/A | p-value | ε4- | ε4+ | p-value | |
| n | 146 | 336 | 150 | -- | 416 | 189 | 27 | -- | 453 | 149 | -- |
| Age (years) | 70.15 (8.86) | 70.82 (8.69) | 70.40 (8.39) | 0.709 | 70.30 (8.82) | 71.45 (8.52) | 68.54 (6.32) | 0.145 | 70.89 (8.84) | 69.86 (8.27) | 0.212 |
| Education (years) | 14.92 (3.11) | 15.36 (2.80) | 15.36 (3.15) | 0.294 | 15.29 (2.96) | 15.13 (2.99) | 15.72 (2.70) | 0.585 | 15.19 (2.97) | 15.55 (3.07) | 0.208 |
| Sex (F/M) | 101/45 | 225/111 | 96/54 | 0.637 | 276/140 | 128/61 | 18/9 | 0.946 | 304/149 | 93/56 | 0.295 |
| MMSE | 28.72 (1.20) | 28.72 (1.20) | 28.56 (1.32) | 0.390 | 28.62 (1.28) | 28.74 (1.15) | 29.15 (0.77) | 0.071 | 28.66 (1.24) | 28.68 (1.25) | 0.914 |
|
| |||||||||||
| CLU | CR1 | PICALM | Total | ||||||||
|
| |||||||||||
| T/T | C+ | p-value | G/G | A+ | p-value | C/C | T+ | p-value | |||
|
| |||||||||||
| n | 103 | 527 | -- | 213 | 417 | -- | 151 | 478 | -- | 632 | |
| Age (years) | 70.65 (8.11) | 70.55 (8.75) | 0.982 | 70.30 (8.90) | 70.70 (8.52) | 0.854 | 69.42 (8.69) | 70.95 (8.59) | 0.129 | 70.56 (8.65) | |
| Education (years) | 14.92 (2.80) | 15.33 (2.98) | 0.182 | 15.41 (3.02) | 15.19 (2.92) | 0.282 | 15.52 (2.93) | 15.18 (2.97) | 0.310 | 15.26 (2.96) | |
| Sex (F/M) | 65/38 | 355/172 | 0.428 | 137/76 | 283/134 | 0.408 | 96/55 | 323/155 | 0.314 | 422/210 | |
| MMSE | 28.71 (1.12) | 28.68 (1.25) | 0.387 | 28.76 (1.27) | 28.65 (1.20) | 0.222 | 28.69 (1.24) | 28.68 (1.22) | 0.356 | 28.68 (1.23) | |
Abbreviations: n = total number; COMT = Catechol-O-methyl transferase; BDNF = Brain-derived neurotrophic factor; APOE = Apolipoprotein E; CLU = Clusterin; CR1 = Complement receptor 1; PICALM = Phosphatidylinositol-binding clathrin assembly protein; p < .05; MMSE = Mini-Mental State Exam; Standard deviations are in parentheses.