Table 2.
Cognitive Aging-Genetic Risk Score (CA-GRS) effect model estimates for low and high Alzheimer’s disease-Genetic Risk Score (AD-GRS) as separated by APOE ε4− and ε4+ groups.
| Intercept | Slope | Model Fit Statistics | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| β | SE | p | β | SE | p | H0 value | Free Parameters | −2LL | AIC | BIC | |
| APOE ε4− group | −1432.04 | 32 | 2864.08 | 2928.08 | 3059.58 | ||||||
|
| |||||||||||
| Low AD-GRS: CA-GRS | 0.248 | 0.166 | 0.135 | 0.012 | 0.011 | 0.279 | |||||
| Low AD-GRS: Sex | 0.031 | 0.284 | 0.912 | −0.004 | 0.017 | 0.797 | |||||
|
| |||||||||||
| High AD-GRS: CA-GRS | 0.006 | 0.058 | 0.919 | 0.002 | 0.003 | 0.599 | |||||
| High AD-GRS: Sex | −0.207 | 0.118 | 0.080 | −0.011 | 0.006 | 0.050 | |||||
|
| |||||||||||
| APOE ε4+ group | −490.72 | 32 | 981.44 | 1045.43 | 1141.56 | ||||||
|
| |||||||||||
| Low AD-GRS: CA-GRS | 0.300 | 3.393 | 0.930 | 0.001 | 0.122 | 0.994 | |||||
| Low AD-GRS: Sex | 0.792 | 2.495 | 0.751 | 0.017 | 0.114 | 0.883 | |||||
|
| |||||||||||
| High AD-GRS: CA-GRS | −0.396 | 0.151 | 0.009 | −0.015 | 0.007 | 0.045 | |||||
| High AD-GRS: Sex | 0.058 | 0.239 | 0.808 | 0.002 | 0.012 | 0.853 | |||||
Abbreviations: Est. = regression estimate; SE = standard error; H0 = log likelihood; −2LL = −2 log likelihood; AIC = Akaike Information Criteria; BIC = Bayesian Information Criteria; COMT = Catechol-O-methyltransferase; BDNF = Brain-derived neurotrophic factor; APOE = Apolipoprotein E; CLU = Clusterin; CR1 = Complement receptor 1; PICALM = Phosphatidylinositol-binding clathrin assembly protein. CA-GRS = COMT + BDNF; AD-GRS = CLU + CR1 + PICALM.