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. Author manuscript; available in PMC: 2019 Feb 26.
Published in final edited form as: Dev Cell. 2018 Feb 26;44(4):433–446.e7. doi: 10.1016/j.devcel.2018.01.021

Figure 7. Model of cardiomyocyte polyploidization as a barrier to heart regeneration.

Figure 7

(A) Hearts composed almost exclusively of diploid cardiomyocytes (1x2c), such as those in the adult zebrafish and mouse neonate, regenerate efficiently after amputation through myocardial proliferation. (B) In mosaic hearts composed of diploid (GFP−) and polyploid-enriched (GFP+) cardiomyocyte populations, diploid cardiomyocytes proliferate actively to replace injured muscle, with minor contributions from the polyploid-enriched population. (C) Minimizing the proportion of diploid cardiomyocytes in the zebrafish heart, a situation similar to that in adult mammals, including humans, results in reduced cardiomyocyte proliferation and persistent scarring. Dashed line, plane of amputation; dark area, amputated tissue; blue boxes, regenerated myocardium; red and green cells, diploid and polyploid-enriched cardiomyocyte populations.