. Author manuscript; available in PMC: 2018 Feb 28.

Published in final edited form as: Nat Rev Urol. 2016 Oct 25;14(2):107–119. doi: 10.1038/nrurol.2016.199

Table 1.

Pharmacological characteristics of statin medications^2,14,15

Statin type	Rate of use^* (%)	Solubility	IC₅₀ for HMG-CoA reductase (nM)	Systemic bioavailability (%)
Simvastatin	42.0	Lipophilic	11.2	<5
Atorvastatin	20.2	Lipophilic	8.2	~14
Pravastatin	11.2	Hydrophilic	44.1	17
Rosuvastatin	8.2	Hydrophilic	5.4	~20
Lovastatin	7.4	Lipophilic	2.7–11.1	<5
Pitavastatin	NR	Lipophilic	6.8	>60
Fluvastatin	NR	Lipophilic	27.6	24

Rate of use in US adults aged ≥40 years reporting to take a cholesterol-lowering medication in the past 30 days (2011–2012).

IC₅₀, half maximal inhibitory concentration; NR, not reported.