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. Author manuscript; available in PMC: 2018 Mar 27.
Published in final edited form as: Sci Transl Med. 2017 Sep 27;9(409):eaan0241. doi: 10.1126/scitranslmed.aan0241

Fig. 4. Histogram of liver HBV mRNA paired-end sequencing reads in HBeAg positive and negative chimpanzees.

Fig. 4

The HBV mRNA and HBV protein open reading frames are positioned relative to the coordinates of the HBV genome. The mRNA sequencing read histograms are shown for HBeAg positive chimpanzees 4x0139, A2A004, A3A006 and A4A014; for HBeAg transitional chimpanzee 89A008; and for HBeAg negative chimpanzees 88A010, 95A010 and 95A008. Locations of the DR1 sequence (red line), HBV PAS (brown dashed line) and binding sites for the siRNAs in ARC-520 (siHBV-74 and siHBV-77) are indicated.