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Schematic diagram of the effects of CrVI on the expression of various apoptotic and cell survival proteins in placenta on gestation day 18.5. Briefly, CrVI induced apoptosis of the trophoblasts in the fetal compartments (LZ and BZ) through a casp-3-independent and AIF/p53-dependent mechanisms. Whereas, CrVI induced apoptosis in the maternal compartment through a casp-3-dependent and AIF/p53-dependent mechanisms.
