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. Author manuscript; available in PMC: 2018 Oct 24.
Published in final edited form as: Cell Rep. 2017 Oct 24;21(4):878–890. doi: 10.1016/j.celrep.2017.10.012

Figure 4. Effects of optogenetic modulation of SOMs and PVs on adaptive versus non-adaptive neurons (also see Figure S2 and S3).

Figure 4

A-D) Population mean firing rate PSTH in response to tone trains for adaptive (A, C) and non-adaptive neuronal responses (B, D) among the SOM-Cre (A, B) or PV-Cre populations (C, D).

E-H) PSTHs of mean per-neuron difference in firing rate between trials with and without optogenetic suppression of interneurons for the first (red) and last (blue) pip.

I-L) Summary of the per-neuron difference in firing rate between trials with and without optogenetic suppression of interneurons in the first and last tone onset response.

M-P) Effect of SOM (M, O) or PV (N, P) optogenetic suppression on firing rates for all neurons in response to the first (M, N) or last (O and P) tone pip versus the magnitude of firing rate adaptation. Optogenetic effects are measured as difference between the means of trials with and without optogenetic suppression. Adaptation is measured as the difference between firing rate in response to the first and last pip. Each dot represents a neuron-frequency pair. Dot color and fill indicate significant optogenetic modulation or adaptation, respectively. Black: ordinary least squares fit. Asterisks: significance of correlation coefficient of cluster-robust regression.