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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Cell Host Microbe. 2017 Sep 28;22(4):494–506.e8. doi: 10.1016/j.chom.2017.08.020

Figure 4.

Figure 4

In vivo competition of the single CPS-expressing strains with the acapsular and WT strains. 10 strains (8 single CPS-expressing strains, the acapsular strain, and the WT strain) were pooled and inoculated into germ-free mice of 2 genotypes (n=5 mice/group): A) wild-type (all co-housed); B) Rag1−/− (in two cages). All mice were fed a high-fiber diet. Relative abundance of each strain in stool was determined via qPCR. Ciprofloxacin was administered in the drinking water of all mice from days 84–88. C–D) Relative abundance of bacterial strains and relative expression of CPS loci in C) wild-type and D) Rag1−/− mouse stool at days 45, 70, and 92, and from cecal contents at mouse sacrifice (day 92). Data are represented as mean ± SEM. See also Figure S7 and Table S4. LOD: Limit of detection.